Cloned (Comment) | Organism |
---|---|
the soluble ecto-domain of human CD38 is expressed in Pichia pastoris | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromenium | - |
Homo sapiens | |
cyanidin | - |
Homo sapiens | |
delphinidin | - |
Homo sapiens | |
fisetinidin | - |
Homo sapiens | |
kuromanin | - |
Homo sapiens | |
luteolin | - |
Homo sapiens | |
luteolinidin | - |
Homo sapiens | |
malvidin | - |
Homo sapiens | |
additional information | not inhibited by rac-taxifolin, rac-catechin, piceatannol, and trans-resveratrol | Homo sapiens | |
myricetin | - |
Homo sapiens | |
pelargonidin | - |
Homo sapiens | |
peonidin | - |
Homo sapiens | |
petunidin | - |
Homo sapiens | |
quercetagetin | - |
Homo sapiens | |
quercetagetinidin | - |
Homo sapiens | |
quercetin | - |
Homo sapiens | |
robinetin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,N6-etheno NAD+ + H2O | - |
Homo sapiens | epsilon-ADP-ribose + nicotinamide + H+ | - |
? | |
additional information | CD38 is a multifunctional enzyme catalyzing the conversion of NAD(P)+ to three metabolites (cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate and ADP-ribose) | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD38 | - |
Homo sapiens |
NAD(P) nucleosidase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.006 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | luteolinidin | |
0.0063 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | kuromanin | |
0.0082 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | luteolin | |
0.0142 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | quercetagetinidin | |
0.0146 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | delphinidin | |
0.0163 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | pelargonidin | |
0.017 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | malvidin | |
0.0209 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | peonidin | |
0.0218 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | cyanidin | |
0.0248 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | myricetin | |
0.0321 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromenium | |
0.0379 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | quercetin | |
0.0379 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | robinetin | |
0.0392 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | petunidin | |
0.0486 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | quercetagetin | |
0.0703 | - |
at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene | Homo sapiens | fisetinidin |